L. Casey Manning was born in Dillon, South Carolina in 1950 to Paul Manning, Sr. and Harnethea Bethea Manning. He has three children: Charlotte, Casey, Jr. and Morgan.
He attended public schools in Dillon, South Carolina and received a basketball scholarship from the University of South Carolina. He received a Bachelor of Arts Degree in Political Science and History from the University of South Carolina in 1973 and was a scholar athlete during his four-year tenure. He received the Freshman Academic Award and the Outstanding Senior Award. He received his juris doctorate degree from U.S.C. in 1977.
He has served as Constable and Agent with the S. C. Law Enforcement Division, 1973-74; part-time instructor at Florence-Darlington Technical College, 1980; practiced law in Dillon County 1979-83; Assistant Attorney General for S. C. 1988-89; partner with Walker, Morgan and Manning in Lexington 1989-94 and was elected by the General Assembly to the Fifth Circuit in 1994.
He is a member of the South Carolina Bar Association and American Bar Association and is admitted to practice in the United States District Court and the Fourth Circuit Court of Appeals. He serves on the Circuit Court Judges' Advisory Committee; S. C. Commission on Judicial Conduct; S. C. Sentencing Guidelines Commission; Hearing Masters, Rules on Judicial Discipline & Standards; Criminal Docketing Committee; and is Color Analyst for the University of South Carolina basketball games.